Chemotherapy drugs for hpv throat cancer

Sign up Log in laringologie Therapeutic strategies for locally advanced laryngeal chemotherapy drugs for hpv throat cancer. Part 1: Radical treatment Strategii terapeutice în cancerul laringian avansat.

chemotherapy drugs for hpv throat cancer

Corina Ptiu e-mail: corina. The main therapeutic goals are local control and survival, but also the functional organ preservation speech, swallowing and airway patencyif possible.

chemotherapy drugs for hpv throat cancer

To achieve these objectives, the management should be established by a multidisciplinary tumor board, based on the analysis of patient-specific factors age, performance status, comorbidities, and psychosocial supportcancer topography and staging, but also the physician expertise and the availability of rehabilitation services. Regarding the larynx preservation, there are two major therapeutic strategies: total laryngectomy associated with adjuvant radio- and chemotherapy and larynx preservation strategy, which includes neoadjuvant chemotherapy followed by exclusive radiotherapy or concurrent radio-chemotherapy or radio-biotherapy.

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Total laryngectomy can be performed by open surgery or, hpv vaccine hurts order to avoid a wide surgical field and reduce the local morbidity, by transoral techniques. After laryngectomy, the recurrence can be local, at the resection site, nodal, at cervical lymph nodes, or distal, the lung being the most common site of recurrence as a distant metastasis.

To improve locoregional control and survival, adjuvant treatments are proposed, including radiotherapy, chemoand biotherapy.

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Există două metode de tratament al cancerului avansat de laringe: laringectomia totală asociată cu radio-chimioterapie adjuvantă şi prezervarea laringelui, care presupune chimioterapie neoadjuvantă, urmată de radioterapie exclusivă sau radio-chimioterapie concomitentă ori radio-bioterapie. Laringectomia totală poate fi realizată prin chirurgie deschisă abord cervical sau prin abord transoral, pentru a evita complicaţiile locale ce pot să apară ca urmare a unei plăgi extinse.

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Recurenţa post-laringectomie poate fi locală la nivelul zonei de rezecţieganglionară la nivelul reţelei ganglionare cervicale sau distală mai ales la nivel pulmonar. Pentru a îmbunătăţi controlul locoregional şi supravieţuirea pe termen lung, sunt propuse tratamente adjuvante, precum radioterapie, chimioterapie sau bioterapie.

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