About 6 million pa- tients with cancer wart virus that starts with m every year worldwide.
In recent years, the rate of cancer detection has raised up because of progression in diagnostic technologies 1. Gynecological malignancy involving vaginal cancer is uncommon and the most victims are reported from developing countries 2.
There are different risk factors including smoking, poor hygiene, high parity, intimating with several sexual partners, in utero exposed diethylstilbestrol, immu- nodeficiency, genital warts and sexually transmitted Human Papilloma Virus HPV that predispose vaginal cancer.
The condom does not prevent the transmis- sion of HPVs; because the HPVs are able virusi ransomware transmit throughout genital skin to skin contact.
The HPV not only in women but also in men may cause genital cancers. The virus is ubiquitous and can be isolated from different human races and animals 9.
Wart virus that starts with m in recent years have shown that this interaction is more complex, involving multiple cellular and molecular mechanisms. Studiile din ultimii ani au demonstrat că această interacţiune este mai complexă, fiind implicate multiple mecanisme celulare şi moleculare. Infecţia cu virusul imunodeficienţei umane Human Immunodeficiency Virus, HIV este de asemenea o problemă de sănătate globală, Centrul pentru Controlul şi Prevenţia Bolilor Centers for Disease Control and Prevention, CDC raportând în existenţa a aproximativ 36,9 milioane de oameni trăind cu această infecţie, dintre care doar 21,7 milioane se aflau sub tratament. Scopul acestei lucrări este de a rezuma datele de actualitate legate de coinfecţia HIV—HPV, un fenomen comun în care cele două virusuri par să-şi potenţeze reciproc mecanismele patogenice.
The earlier recognition of vaginal cancer was introduced in by Meigs and Graham. However, the illustration of primary vaginal cancer was achieved by Cruveilhier in 19th century.
This type of cancer is often known as the secondary gynecological disease which may occur in the consequence of metastasis from cancerous anus, cervix, colon, endometrium, ovary, rectum and vulva in women. Thus, the primary form of vaginal cancer is rare 6,10, There are different types of primary vaginal cancers Table 1 The previous reports show that squamous cell carci- noma ranks as the most prevalent vaginal cancer with the percentage of about The majority of squamous cell carcinoma is in association with HPV 6.
În centrul Tătărași din Iași, testul este disponibil de luni până vineri, orele Proteinele E6 si E7 produse de wart virus that starts with m HPV cu risc crescut detin un rol esential in carcinogeneza fiind exprimate atat in leziunile cervicale pre-maligne cat si in cele avansate. Genele E6 si E7 se afla sub controlul proteinei codificata de gena E2. Integrarea se produce adesea la nivelul genei E2 care este astfel inactivata; ca urmare a acestui proces rezulta o expresie necontrolata a genelor E6 si E7. Oncoproteinele E6 si E7 perturba ciclul celular prin legarea si inactivarea a doua proteine ale gazdei cu rol important in reglarea diviziunii celulare normale: proteina supresoare tumorala p53 si proteina retinoblastomului pRb.
The average age of mortality for patients with vaginal cancer is recorded about 65 years old 6, There is a direct associa- tion between HPV and cervico-vaginal cancer. In utero contact diethylstilbestrol is the predominant cause of vaginal cancers of melanoma and adenocarcinoma 3,6, HPV family includes more than carcinogenic and non-carcinogenic types.
HPVs have positive tropism to human mucosal and moist membranes and skin.
The low risk carcinogenic types of HPVs are important causative agent for viral warts such as genital warts Table 2 3,9, The aim of this article is to review the subtitle of vaginal cancer staging, epidemiology of HPV vaginal cancers, viral characteristics and pathogenesis of HPV vaginal cancers, clinical demonstrations of HPV vaginal cancers diagnosis, treatment and prevention.