Abstract: Despite the significant progress regarding molecular classifications for colon, pancreatic and gastric cancer, the therapeutic methods arterial, chimio and radioembolizationthe life expectancy of patients with existing liver metastases did not improve significantly. The aim was to analyze the interrelation between the vascularization, mast cells and the histological growth pattern of hepatic metastasis with digestive origins.
Abstract Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node metastasis. Distant metastases through blood with prevalent liver location are detected late in disease progression, in an advanced stage, when therapeutic possibilities are often limited to palliative therapy. Material and methods: The study included a series of patients with liver metastases admitted to the Center of Gastroenterology and Hepatology Iasi between January 1 and October 10, for the identification of primitive tumor.
The distribution of the liver metastasis growth pattern was as follows: colon all 3 typespancreatic replacementgastric pushing type. A significant correlation between mast cell density in the peritumoral area and vascular microdensity in the metastatic domain of all histological growth patterns was found.
Significant correlation between positive mast cells tryptase density and degree of differentiation for the desmoplastic type was noticed. The mast cells may have a prognostic role in this growth pattern and the mast cell inhibitor therapy may gastric cancer metastasis to liver useful.
Keywords: mast cells, liver metastasis, histological growth pattern References: 1. Histologic growth patterns of metastatic carcinomas of the liver.
Dan G. Duda - DF/HCC
Jpn J Clin Oncol; 24—29, Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol; —, Negru Ş: Oncologie generală.
Editura Victor Babeş, Capitolul 6: Invazia locală şi metastazarea, pag Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent findings. Translational gastrointestinal cancer.
Int J Mol Sci. High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases. BMC Cancer.
Anticancer Res. Weidner N, Measuring intratumoral microvessel density.
Methods Enzymol; The histological growth pattern of colorectal cancer liver metastases has prognostic value. Clin Exp Metastasis.
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A microphysiological system model of therapy for liver micrometastases. Exp Biol Med.
MALIGNANT TUMORS OF DIGESTIVE ORGANS AND LIVER METASTASES AT THE TIME OF DIAGNOSIS
Tumor angiogenesis in gastric cancer. Rom J Morphol Embryol.
Since that time, new data have become available, these have been incorporated into the Monograph, and taken into consideration in the present evaluation.
Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay. Int J Dev Biol. Synovial procollagenase activation by human mast cell tryptase dependence up on matrixmetallo-proteinase 3 activation. J Clin Investig.
Dan G. Duda
The significant role of mast cells in cancer. Cancer Metastasis Rev.
Duda's group is focused on studies of tumor interaction with its microenvironment, with the goal of identifying the cellular and molecular mechanisms of: 1 local tumor progression in liver cancers and metastatic tumor progression in other gastrointestinal cancers and in prostate and breast malignanciesand 2 treatment resistance in advanced cancers. The ultimate goal is to identify and validate targets for combination therapy with radiation and immunotherapy in preclinical studies, and in parallel conduct studies of biomarkers of response in correlative clinical gastric cancer metastasis to liver. He has been invited to present his results at over local, national and international meetings, including Grand Rounds, Plenary Talks and Keynote Lectures.
Evaluation of endoscopic biopsy in gastric lesions with a special reference to the significance of mast cell density. Indian J Pathol Microbiol.
Targeting mast cells tryptase in tumor microenvironment: A potential antiangiogenetic strategy. Biomed Res Int.
Stomach (Gastric) Cancer - Stephanie’s Story
Human mast cells stimulate vascular tube formation. Tryptase is gastric cancer metastasis to liver novel, potent angiogenic factor. Mast cells and angiogenesis in gastric carcinoma.
Personal Habits and Indoor Combustions.
Int J Exp Pathol. Protease-activated receptor-2 is essential for factor VIIa and Xa-induced signaling, migration, and invasion of breast cancer cells.
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