Human papillomavirus infection deficiency.

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Calina Maier, Mihai Mitran, Prof. Radu Vlădăreanu, Prof.

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Materials and method. We included patients diagnosed with high-grade cervical dysplasia who benefited from conization in our clinic. The mean age for our study group was Regarding personal obstetrical history, most of the patients were multiparous The mean age at the first sexual intercourse was Nine patients 3.

Ma­te­riale şi metodă.

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Vârsta medie de debut a vieţii sexuale pentru lotul de studiu a fost de 22,13 ani şi peste jumătate dintre paciente au afirmat neu­ti­li­zarea contracepţiei de barieră.

Cei trei factori pentru care am identificat rele­van­ţă statistică permit conturarea unui model predictiv de risc ce poate fi utilizat în eforturile clinicienilor de pre­ven­ţie a dezvoltării leziunilor cervicale invazive.

Cervical excisional therapy remains the main approach for high-grade CIN, offering not only a histopathological diagnosis, but also allowing to rule out invasive cancer, an evaluation of the resection margins and preserving childbearing capabilities 2.

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The identification of such factors could be valuable in optimizing the follow-up protocol by creating a risk assessment model and also avoiding overtreatment. The inclusion criteria used were: initial diagnosis either cytological or histological of high-grade squamous lesion, conization performed in our hospital setting, histopathological examination and colposcopic examination performed in our hospital, known HPV status before surgery and at least one follow-up visit, a minimum of two follow-up visits at 12 and 24 months after therapyinformed consents for colposcopy, anesthesia and surgical procedures cervical biopsy, endocervical sampling, cervical excision, hysterectomy.

The follow-up protocol consisted of at least two visits at 12 and 24 months after therapy, as recommended by ASCCP guidelines 2. We performed for each human papillomavirus infection deficiency clinical examination, liquid based cervical cytology and HPV testing co-testing. If the co-testing result was abnormal, we performed colposcopy and endocervical curettage with any cervical lesion identified being biopsied.

The data obtained were statistically analyzed using standard methods of descriptive statistics means, median, SD.

The independent predictive factors were identified using the logistic multivariate regression analysis. Results The mean age for our study group was The level of education analysis showed that Regarding the residence status, most of the patients lived in an urban setting patients; Regarding the sexual behaviour, 28 human papillomavirus infection deficiency 9.

Also, the latency between the age at first pregnancy and the age at first sexual intercourse less than two years was declared by 87 patients. The mean age at first pregnancy was All demographic characteristics of our study group are presented in Table 1.

human papillomavirus infection deficiency

Tabel 1. Demographic caracteristics After a mean follow-up period of No difference was observed for the use of contraceptive pills for human papillomavirus infection deficiency period longer than two years and for having more than five sexual partners.

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All six HIV-positive patients had been diagnosed with persistent disease during follow-up. These correlations can be seen in Table 2. Tabel 2.

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The lack of medical information that patients tend to have in our country especially in rural areaswhich correlates with cervical cancer screening deficiency, explains the still alarming high rates of invasive cervical cancer High human papillomavirus infection deficiency of smoking metabolites such as nicotine, phenols and other hydrocarbons were identified in the cervical mucus of smoking women The mechanisms involved include the direct carcinogenic effect on the cervical epithelial cells 12but also on Langerhans cells which might contribute to persistence of HPV infection A possible explanation for this result is that the relationship between oral contraceptive use and the risk for cervical human papillomavirus infection deficiency is linear, dose-dependent and reversible at years after being stopped, and we did not assess in human papillomavirus infection deficiency study the exact time which elapsed from their first usage.

We did not analyze in this study the influence of the CD4 human papillomavirus infection deficiency, viral load or antiviral therapy. Specifically, the patient with Hodgkin lymphoma underwent two cervical excision procedures and then abdominal total hysterectomy with further negative vaginal cytology reports.

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At present time, she is still in remission and continues the follow-up protocol in our clinic Furthermore, immunosuppressed patients especially HIV-positive patients are a special category which warrants attention. Conflict of interests: The authors declare no conflict of interests.

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Chapter 4: Cervical Cancer: Epidemiology and Etiology. J Low Genit Tract Dis. Long-term risk of invasive cervical cancer after treatment of squamous cervical intraepithelial neoplasia.

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Cox TJ. Chapter Management of lower genital tract neoplasia. J Gynecol Oncol. Recurrent high-grade cervical lesion after primary conization is squamous papilloma differential diagnosis with persistent human papillomavirus infection in Norway.

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