Material and method: Sixty patients were included in our study.
The virus infects basal epithelial cells of stratified squamous epithelium. HPV E6 and E7 oncoproteins are the critical molecules in the process of malignant tumour formation. Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell papillomavirus infection increases regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses.
All of the patient underwent colposcopy-guided biopsy to asses the grade of CIN. For the immunohistochemistry exam papillomavirus infection increases used p16INK4A and Ki antibody and their expression was semiquantitatively classified in 4 classes: 0, 1, 2 and 3. Results: 7 of our cases were benign Cancer burden in the year The global picture.
Eur J Cancer ; 37 Suppl 8: S4 Estimates of cancer incidence and mortality in Europe in Eur J Cancer ; 99 Richart RM. A modified terminology for cervical intraepithelial neoplasia.
Obstet Gynecol ; Ann Oncol ; 21 3 : Evaluation of p16INK4a and pRb expression in cervical squamous and glandular neoplasia.
Fiziopatologia infecţiei cu HPV apărute în contextul pacienţilor seropozitivi pentru infecţia HIV
Hum Pathol ; 35 6 : Ki immunoquantitation in cervical intraepithelial neoplasia CIN : a sensitive marker for grading. J Pathol ; Hum Pathol ; Expression of p16 and Ki in relation to the grade of cervical intraepithelial neoplasia and high-risk human papillomavirus infection.
J Gynecol Oncol ; Overexpression of p16INK4a as a specific marker for dysplastic and neoplastic epithelial cells of the cervix uteri.
Int J Cancer ; J Clin Pathol ; Cancer Treat Rev ; 35 3 : Am J Surg Pathol ; 31 papillomavirus infection increases : P16INK4A Immunochemistry improves interobserver agreement in the diagnosis of cervical intraepithelial neoplasia. Am J Surg Papillomavirus infection increases ; 26 11 : Validation of p16INK4a as a marker of oncogenic human papillomavirus infection in cervical biopsies from a population-based cohort in Costa Rica. Cancer Papillomavirus infection increases Biomarkers Prev ; Methods Mol Med ; 73 Kalof AN, Cooper Papillomavirus infection increases.
Adv Anat Pathol ; J Pathol ; Evaluation of MIB-1 Positive cell clusters as a diagnostic marker for cervical intraepithelial neoplasia.
Panjkoviæ M, Ivkoviæ-Kapicl T. Ki expression in squamous intraepithelial lesions of the uterine cervix.
- Department of Ophthalmology, Grigore T.
- Inverted papilloma palatine tonsil
- Respiratory papillomatosis with lung
Arch Oncol ; 14 12 : 23 Diagnostic accuracy of cervical low-grade squamous intraepithelial lesions is improved with MIB-1 immunostaining. Am J Surg Pathol ; 26 1 : Mehrotra A, Mati GM.
HPV and Cervical Cancer: 25 Years from Discovery to Vaccine
Assessment of monoclonal antibody MIB-1 labeling indices in cervical intraepithelial lesions of the uterine cervix in paraffin section. J Obstet Gynecol India ; 58 4 : Ki quantitative evaluation as a marker of cervical intraepithelial neoplasia and human papillomavirus infection.
Int J Gynecol Cancer ; 20 1 : Mod Pathol ; 16 7 :