Ovarian cancer epithelial cells.

ovarian cancer epithelial cells

Several previous studies have identified an association between endometriosis and the development of ovarian carcinomas.

The purpose of this paper is to quantify the in­ci­dence of different histological types of ovarian tumors and to demonstrate the clinical importance of an effective screening program, considering the paucisymptomatic na­ture of this pathology. The incidence of ovarian epithelial tumors varied across age groups, our study group including women aged between 34 and 64 years old. Knowing the age distribution plays an important role in the implementation of screening pro­grams.

This study aims to follow-up the prevalence of endometriosis and the histological features in ovarian tumors. Materials and method.

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The study group included 50 patients from the County Emergency Hospital of Galaţi diagnosed with different histological types of ovarian tumors of the surface epithelium during the period The cases were ovarian cancer epithelial cells in order to highlight the presence of endometriosis and the different histopathological changes.

The average age of patients in the group with endometriosis associated with ovarian tumors was From the seven cases of tumors associated with endometriosis, two presented areas with atypia, considered premalignant lesions.

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Based on data obtained, we can conclude that endometriosis with atypia can be a precursor to the occurrence of type I ovarian carcinomas.

Keywords endometriosis, ovarian cancer, atypical endometriosis, premalignant ovarian cancer epithelial cells Rezumat Introducere.

Mai multe studii anterioare au identificat o asociere între endometrioză şi dezvoltarea carcinoamelor ovariene. Acest studiu urmăreşte prevalenţa endometriozei şi caracteristicile histologice în tumorile ovariene. Materiale şi metodă.

În lotul de studiu au fost ovarian cancer epithelial cells 50 de paciente diagnosticate cu ovarian cancer epithelial cells tipuri histologice de tumori ovariene ale epiteliului de suprafaţă în perioada la Spitalul Judeţean de Urgenţă din Galaţi.

Cazurile au fost reanalizate în vederea evidenţierii prezenţei endometriozei, precum şi a diferitelor modificări histopatologice ale acestora. Vârsta medie a pacientelor a fost 59,4±11,35 ani în lotul pacientelor care au prezentat endometrioză asociată şi 59,5±13,4 types danemie în lotul pacientelor care au prezentat doar tumori ovariene.

Din cele şapte cazuri de endometrioză, în două cazuri au fost evidenţiate zone cu atipii, considerate leziuni premaligne.

The utility of immunohistochemistry in the diagnosis of ovarian carcinoma

Identificarea endometriozei cu atipii ovarian cancer epithelial cells cele două cazuri — unul diagnosticat cu carcinom cu celule clare, iar celălalt cu carcinom endometrial, ambele incluse în ovarian cancer epithelial cells I de cancer ovarian — demonstrează faptul că endometrioza cu atipii poate fi un precursor în apariţia carcinoamelor ovariene de tip I.

Endometriosis is a gynecological condition, being characterized from a histopathological point of view by the presence of glandular structures at the level of the endometrium and stroma in ectopic locations, such as ovary, pelvis, bladder, Fallopian tube, ovary representing the most common location 4,5.

The literature comprises multiple studies highlighting the link between the presence of endometriosis and its malignant transformation in the ovary, although other studies ovarian cancer epithelial cells not identified associations between these two 6,7. It is estimated that the risk of malignant transformation of endometriosis is comprised between 0. Endometriosis with atypia is described as a preneoplastic lesion and is considered an intermediate pathway for the development of ovarian carcinoma 3.

InSampson described for the first time the implications of endometriosis in neoplastic lesions by establishing several important criteria: the presence of endometriosis and the tumor in the same ovary, a similar histological pattern, the exclusion of the presence of tumor metastasis from other locations 8. InScott added one more criterion: highlighting the continuity between the benign and the malignant epithelium 9.

Ovarian Cancer

Ovarian cancer epithelial cells from endometriosis was proposed as a preneoplastic lesion between endometriosis and ovarian cancer, as it refers to two major histological changes: cytological atypia and architectural atypia known as hyperplasia Cytological atypia is highlighted in the epithelium of an endometrial cyst, while the hyperplasia resembles to the hyperplasia present in the endometrium simple or complex with or without atypia Materials and method The study comprises patients of the Emergency County Hospital of Galaţi diagnosed with ovarian carcinoma during the period January — December The histopathological results were analyzed retrospectively to identify the presence of endometriosis.

A number of diagnosed cases and ovarian tumors ovarian cancer epithelial cells analyzed in order to identify the presence or absence of endometriosis, as well as the relationship between these two, based on the criteria listed before. In this study, we included and evaluated a number of 50 patients diagnosed with epithelial ovarian carcinomas, but also ovarian cancer epithelial cells borderline ovarian tumors. The present study aims to identify the presence of endometriosis outbreaks with or without cytological or architectural atypia hyperplasia.

Each case was evaluated from a histopathological point of view. The number of paraffin blocks varied depending on the surgical pieces, being between 4 and 12 blocks, the slides resulting from the section of these blocks being processed and colored using the classic hematoxylin and eosin coloration.

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The following clinical and pathological data of the patients were taken into account: age, menopausal status, tumor histological type, tumor grading at the time of ovarian diagnosis. The staging was made retrospectively according to the system of the International Federation of Gynecology and Obstetrics FIGO after cases have been analyzed.

The histological classification of ovarian carcinomas was based on the classification WHO of ovarian tumors. Results The histopathological evaluation performed on the group of 50 patients during the period has the following results: 45 cases were diagnosed with malignant tumors, 5 cases being borderline tumors. Figure 1. Figure 2. From ovarian cancer epithelial cells seven patients with endometriosis, None of the cases of borderline mucinous tumors, mucinous carcinoma, and undifferentiated carcinoma presented associated endometriosis outbreaks Table 1.

Table 1. The presence of endometriosis in the appendages was Two of the seven cases in which the areas of endometriosis were visualized presented also endometriosis with atypia one case of complex hyperplasia, and the other with cytological atypia in the wall of an endometrial cyst.

In our study, the average age at the renal cancer palliative care of diagnosis was One of the studies reported in the literature identified an average age of ovarian cancer epithelial cells The association between endometriosis and ovar­ian cancer is reported in the ovarian cancer epithelial cells studies under two categories.

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In all other cases, the ovarian tumor literally coexisted with endometriosis without the identification of a transition 13, Ogawa et al. In this study, the transition between endometriosis and ovarian carcinoma was present only in two cases, representing According to the classification proposed by Kurman and Shih, all identified ovarian tumors were classified into two large groups: type I and type II. Type I contains low-grade serous carcinoma, endometrioid carcinomas, clear cell carcinomas, mucinous carcinomas, and transitional type carcinomas, while in type II the ovarian tumors are comprising high-grade serous carcinoma, mixed malignancies and detoxifiere mentala carcinomas Most studies on this topic show that the prevalence of endometriosis is higher in the case of endometrioid carcinomas and especially those with clear cells compared to the mucinous and serous carcinomas 2,5,12, Another study showed that This study comprises also an evaluation of the presence or absence of endometriosis in patients with ovarian tumors and the transition between endometriosis outbreaks and ovarian tumors.

According to a study by Van Gorp et al. Category A consists of cases with areas of endometriosis present in the same ovary, with areas of histological transition between endometriosis and ovarian tumor. Category B contains cases with outbreaks of endometri­osis without transition between endometriosis and tumor, while category C contains cases with endometriosis present in any other location, for example in the pelvis, the contralateral ovary ovarian cancer epithelial cells extragonadal endometriosis 5.

In our study, from the seven cases of carcinomas presenting endometriosis outbreaks associated, in two cases there were highlighted areas of transition between the benign and the malignant process identified by the criteria listed by Sampson and Ovarian cancer epithelial cells, and included in category A.

From the five cases, the remaining ovarian cancer epithelial cells were classified in category B, and one case in category C. The presence of areas of endometriosis with atypia was made based on criteria which included the increase in volume human papillomavirus (hpv) and genital warts hyperchromatic of nuclei, or contrary, hypochromic nuclei, eosinophilic cytoplasm, branching and agglomeration or stratification, all according to the criteria suggested by LaGrenada and Silverberg The study is limited due to the low number of cases for some of the histological types.

Conclusions Endometrioid and clear cell carcinoma are ovarian cancer epithelial cells most common types of tumors in association with endometriosis included in type I tumors, according to the classification proposed by Kurman and Shih. In this study, we encountered two cases of atypical endometriosis, a case of clear cell carcinoma, and one case of endometrioid carcinoma.

In both cases, we observed the transition from a preneoplastic lesion to the ovarian cancer epithelial cells lesion, which makes us think that endometriotic atypia can be considered a precursor to type I carcinomas.

Conflict of interests: The authors declare no conflict of interests. The molecular signature of endometriosis-associated endometrioid ovarian cancer differs significantly from endometriosis-independent endometrioid ovarian cancer.

Fertil Steril.

Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale

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  • Incidenţa endometriozei şi a endometriozei atipice în cazul tumorilor ovariene epiteliale
  • Que es cancer germinal

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Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

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Utilitatea imunohistochimiei în diagnosticul carcinomului ovarian

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