Although not-fulfilling all "the Amsterdam offers a homogenous but apparently rigid frame, considering criteria" for eligibility in the HNPCC group, the patients current molecular genetics research.
Thus, more and more with colo-rectal cancer and positive family history showed patients that do not fulfil entirely those criteria and an morphoclinical features which suggested poor prognosis important number of patients with sporadic cancers are found compared to those with negative family history. A comparative analysis of the morphoclinical Key words features in non-polyposis colo-rectal cancer patients with Hereditary colo-rectal cancer - Amsterdam Criteria - positive family histories which fulfil cancer genetic percentage or partially prognosis "the Amsterdam criteria" versus the patients with sporadic non-polyposis colorectal cancers.
Patients and methods. We performed a retrospective a n a l y s i s cancer genetic percentage c o l o - r e c t a l c a n c e r p a t i e n cancer genetic percentage s o p e r a t e d consecutively by the same surgical team. The patients were Rezumat allocated into two groups: group A - patients with colo Introducere.
The cases respecte "criteriile Amsterdam" care asigură un cadru with familial polyposis and those with uncertain family history omogen dar aparent rigid în lumina noilor cercetări de were excluded. We analyzed comparatively the differences genetică moleculară.
Astfel, la tot mai mulţi pacienţi care in sex, age, stage, tumour site, pathological characteristics. A number of colo-rectal cancer patients Scopul cercetării. Cancer genetic percentage comparativă a particularită underwent surgery between and their medical ţilor morfo-clinice la pacienţi cu cancere colo-rectale non- records were assessed retrospectively.
The group A contained polipoase cu antecedente heredo-colaterale pozitive şi care 30 patients with colo-rectal cancer and positive family întrunesc parţial sau total "criteriile Amsterdam" faţă de history and group B consisted of patients with colo pacienţii cu cancere colo-rectale non-polipoase sporadice.
We noted Material şi metodă.
Au fost analizate retrospectiv important differences between the two groups regarding age cazurile de cancere colo-rectale operate consecutiv de in group A we found significantly more patients aged under aceeaşi echipă chirurgicală. Au fost Vol. Mircca Cazacu antecedente heredo-colaterale incerte. Grupul A a cuprins 30 family history were excluded.
We analyzed comparatively pacienţi cu cancere colo-rectale şi antecedente heredo- the differences in sex, age, Dukes stage, tumour site, colaterale pozitive iar grupul B a cuprins de pacienţi pathological features. Deosebiri importante au fost decelate între cele significant. Their medical records were multe cazuri cu structură histologică de carcinom difuz, analyzed retrospectively. The group A consisted of 30 patients with positive family Concluzii.
Deşi pacienţii noştri cu cancere colo-rectale history and group B contained patients with negative şi antecedente familiale pozitive nu întrunesc toate cancer genetic percentage history. The analysis of the morpho-clinical elements "criteriile Amsterdam" pentru încadrarea în grupul CCENP showed: aceştia prezintă particularităţi morfo-clinice de gravitate 1. Sex - we noted a relatively uniform distribution of the crescută faţă de pacienţii fără antecedente heredo-colaterale.
Age - the median age was Staging - considering the distribution of the cases in entirely "the Amsterdam criteria".
The relationship with the "Amsterdam Criteria": there rectal cancer in order to detect the differences between was no patient in group A that fulfilled all "The Amsterdam patients with positive malignant family history and those Criteria": 5 patients fulfilled 1 criteria, 9 patients fulfilled 2 with cancer genetic percentage such history.
Discussions Material and methods The scientific approach of the hereditary colo-rectal We analyzed retrospectively cases of colo-rectal cancer cancers has changed very much after the discovery of tumor operated on by the same surgical team.
The patients were microsatellite instability. Hereditary non-polyposis colo-rectal cancer between dogma cancer genetic percentage reality There are certain conditions which need to be fulfilled We consider that by confronting this situation, we can in order to permit the allocation of a patient in the HNPCC apply one of the new clinical subdivisions of colorectal group conditions defined in as "The Amsterdam cancer which allows the allocation in one of the 5 groups: Criteria".
The presence of colo-rectal cancers pathologically 2 HNPCC suspect - the cases that do not comply with all confirmed in at least three cancer genetic percentage of the family, one of the standard criteria; them being a first degree relative to the others. Colo-rectal cancers present at least in two successive comply with the standard criteria but have relatives suffering generations.
At least one of the family members diagnosed when 4 juvenile types - cases that fulfil only one criteria and aged under Although none of gene mutation This aspect has cancer genetic percentage - the estimation of individual risk, currently done by consequences regarding the indication of genetic testing of means of genetic testing, with all its social and economical all family members and the eventual costs of screening consequences, evaluation of certain risk groups 5.
Pulmonary cancer tumor markers
Thus we use on a Thus, taking as genetic criteria the presence of mismatch- large scale family history investigation and also laboratory repair-gene mutation, the situations which suggest the tests and we hope the future will bring us new techniques presence of a hereditary colorectal cancer cancer genetic percentage such as the detection cancer genetic percentage human leucocyte antigens as genetic - the presence of colorectal cancer in at least 3 family markers cancer genetic percentage colo-rectal carcinoma Among the 30 cases operated by us follow-up.
References Facing this diversity we compared the main morpho- 1.
Vincent T. DcVita Jr. The differences were Hereditary colorectal ; Gut ; Familial and hereditary factors in colorectal ovarian cancer quilt a new 4.
Prevenirea cancerului prin intermediul unor programe de screening
Baba S. Hereditary nonpolyposis colorectal cancer: an update. Dis Colon Rectum ; 40 10 Suppl : S Br J Cancer ; 73 Suppl 26 Hereditary nonpolyposis Genetics of colorectal cancer.
Non-polyposis and polyposis criteria show extremely low frequency of mismatch-rcpair-gcnc forms of hereditary colorectal cancer.
Ned Tijdschr Gcnecskd mutations. Am J Hum Genet ; Family history Genetic testing in characteristics, tumor microsatcllitc instability and gcrmlinc hereditary colorectal cancer: indications and procedures.
Pulmonary cancer tumor markers
Gastroenterol ; Hum Genet ; Varying features of clinical consequences of predictive molecular testing. Int J early agc-of-onsct "sporadic" and hereditary nonpolyposis colo- Colorectal Cancer genetic percentage ; Dis Colon Rectum ; Human 8. Hereditary background of Dis Colon Rectum ; Cancer genetic percentage Tijdschr Gcnecskd Related Papers.