Colorectal cancer oligometastatic

Oncolog-Hematolog Nr. 34 (1/) by Versa Media - Issuu

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Global visibility: Building on past successes and widespread international coverage garnered by previous Congresses, the Congress in Amsterdam promises an even stronger media campaign to increase exposure. No limits: The European Cancer Congress is without boundaries. A record number of participants from countries attended Stockholm. Top quality content: The comprehensive Scientific Programme of excellence is being devised based on your input and feedback by leading scientific experts in our field, ensuring exceptional quality and educational opportunity.

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On day one hear from industry leaders working at the forefront of oncology co-development. On day two our distinguished speakers will explore case studies of global clinical trials, strategies to overcome operational challenges and methods to ensure effective patient recruitment and retention.

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The meeting will bring together leading scientists from across these areas for a unique opportunity to interact and stimulate further integration of these efforts. European Cancer Genomics research is particularly strong in the Heidelberg area, with three International Cancer Colorectal cancer oligometastatic Consortium www. As in our meeting, a large number of renowned speakers will be invited, with a strong representation of overseas speakers.

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Short oral communications selected from submitted abstracts will enable registered participants to present their own data.

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The colorectal cancer oligometastatic articles Hemostatic derangements in patients with solid malignant tumors Mazin R.

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Mohammed1, Saad S. Mansoor1, Mustafa Ghany Taher2 1.

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Baqubah Teaching Hospital, Diyala, Iraq 2. Cancer patients show an increased susceptibility to thromboembolic diseases. Although clinical symptoms occur less frequently, disorders of coagulation are very common in cancer patients.

The aim of the study was to determine the colorectal cancer oligometastatic of hemostatic derangements in patients suffering from solid malignant tumors. This case-controlled study was conducted on patients with solid malignant tumors colorectal cancer oligometastatic presented to Al-Yermok Teaching Hospital and Hospital of Radiation and Nuclear Medicine in Iraq, from January to July Forty colorectal cancer oligometastatic were included in the study colorectal cancer oligometastatic the control group included fifteen age and gender matched healthy volunteers.

Platelet count was determined from blood sample, while tests for prothrombin time PTactivated partial thromboplastin time aPTTthrombin time TTfibrinogen and D-dimer were conducted on plasma. Fourteen patients had slight concurrent bleeding; only one patient gave history of recurrent attacks of deep venous thrombosis. The mean PT, aPTT and TT were higher in subjects with malignancies as compared to the healthy controls; and these variables were also higher in those with evidence of intravascular coagulation and fibrinolysis ICF as compared to those without ICF syndrome.

Hemostatic derangement is common in patients with a wide variety of malignancies. The plasma D-dimer test with other indices of DIC syndrome forms a good and simple applicable colorectal cancer oligometastatic of tests for assessment of ICF syndrome. Keywords: Hemostatic derangement; Solid malignant tumor; D-dimer Introducere. Pacienţii cu cancer prezintă o susceptibilitate crescută pentru dezvoltarea bolilor tromboembolice.

Deși simptomele clinice apar mai rar, problemele de coagulare sunt foarte comune în rândul pacienţilor cu cancer. Scopul studiului a fost să determine prezenţa afecţiunilor hemostatice la pacienţii care prezintă tumori maligne solide.

Acest studiu caz-control a fost realizat cu participarea pacienţilor cu tumori maligne solide care s-au prezentat la Spitalul Universitar Al-Yermok și colorectal cancer oligometastatic Spitalul de Iradiere și Medicină Nucleară din Irak, între ianuarie și iulie Patruzeci de cazuri au fost incluse în acest studiu, iar grupul de control a fost format din 15 voluntari sănătoși ajustaţi pentru vârstă și sex.

Paisprezece pacienți au prezentat sângerare concomitentă ușoară; doar un singur pacient a prezentat un istoric de tromboză venoasă recurentă. Media PT, aPTT și TT a fost mai mare colorectal cancer oligometastatic subiecţii cu cancer în comparaţie cu subiecţii de control; aceste variabile au fost de asemenea mai ridicate la cei cu fibrinoliză și coagulare intravasculară ICF în comparaţie cu cei fără sindromul ICF.

Afectările hemostatice sunt comune în cazul unei varietăţi de malignităţi. Testul pentru D-dimeri împreună cu alţi indici ai sindromului DIC formează un bun panel de teste de laborator pentru diagnosticul sindromului ICF. Cuvinte-cheie: afectare hemostatică, tumori maligne solide, D-dimer Introduction Patients with solid malignant tumor show an increased susceptibility to thromboembolic events as compared to the general population.

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Although clinical 14 symptoms occur less frequently, disorders of coagulation are very common in such patients 1. Thromboembolism is one colorectal cancer oligometastatic the most common causes of death in cancer patients 1. The incidence of TED in postmortem studies of cancer patients is considerably higher. A wide range of coagulation disturbances can papilloma meaning in mandarin in patients with malignancies, which can predispose patients to hemorrhage or thrombosis 6.

Cooper and associates classified this syndrome into three groups; decompensated which is defined by depressed platelets or fibrinogen levels along with other hemostatic abnormalities, compensated colorectal cancer oligometastatic which platelets or fibrinogen values are normal but other hemostatic tests are abnormally prolonged, and overcompensated whereas the platelets or fibrinogen are increased together with other hemostatic abnormalities. This has also been correlated with the conventional terms; acute, sub-acute and chronic DIC with decompensated, overcompensated and compensated DIC respectively 7,8.

The colorectal cancer oligometastatic of the study were to determine the presence of hemostatic derangements in patients suffering from solid malignant tumors. A secondary aim was to elucidate the association of intravascular coagulation and fibrinolysis ICF with grade of tumor, histologic type of tumor and presence of metastasis.

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Methods and materials This case-controlled colorectal cancer oligometastatic was conducted during a period of six months, from January to July A total of 40 patients with solid malignant tumors of various organs were included in this study; 13 of these patients were admitted to Al-Yermok Teaching Hospital in Baghdad and 27 patients were from the Hospital of Radiation and Nuclear Medicine in Baghdad. Fifteen age and sex matched healthy volunteers were included in this present study as control group, 9 colorectal cancer oligometastatic and 6 females, the age range was years for males and years for females.

We excluded patients with co-morbid conditions that could affect coagulation profile, or patients using certain medication or those with history of coagulation disorders. The platelet count was conducted on blood whereas plasma was isolated for remaining laboratory tests including prothrombin time PTactivated partial thromboplastin time aPTTthrombin time TTfibrinogen and D-dimer.

Patients were considered to have evidence of intravascular coagulation and fibrinolysis ICF syndrome if their plasma D-dimer level was more than 0. The concept of ICF of Owen and Bowie was adopted and their classification of overcompensated, compensated and decompensated ICF was tested 8,9 and an attempt was made to identify those key tests that might enable us to discover patients with coagulation problems.

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The D-dimer and platelets were used as indicators and separated the patients into four groups. Patients with no ICF normal D-dimer 2. Those with overcompensated ICF elevated D-dimer and elevated platelets count 3. Those with compensated ICF elevated D-dimer but normal colorectal cancer oligometastatic count 4. Those with decompensated ICF elevated D-dimer and decreased platelets count. In this study, the FDP test which was used by Owen and Bowie study 7 has been replaced by D-dimer test for the diagnosis of ICF syndrome because the D-dimer test is regarded now to be more specific for fibrin degradation products whereas the formation of fibrinolytic degradation products FDPX, Y, D and E fragments may be either fibrinogen or fibrin derived following the plasmin digestion 9, Moreover, the criteria of Owen colorectal cancer oligometastatic Bowie for the diagnosis of ICF was utilized, although in recent years many new criteria were added to diagnose ICF 11,12,13 but none of these were applicable in the present study because of the non-availability of some of relevant laboratory tests.

Pooled plasma from at least 4 healthy individuals, were prepared and divided into Hodgkin lymphoma.

Se estimează că Alte tipuri celulare mai puțin frecvente includ papilar, cromofob și tumorile canalelor Bellini ducturile colectare. Carcinomul renal medular este o varianta a carcinomului ductelor colectare și a fost descris inițial ca apărând la pacienții care sunt pozitivi pentru caracterul de siclemie. Carcinomul renal se caracterizează printr-o lipsă de semne de avertizare timpurie, diverse manifestări clinice, precum si rezistenta la radiatii si chimioterapie. Nefrectomia radicala este standardul pentru tumorile mai mari și centrale.

The evidence of thrombosis was encountered in one patient only. Colorectal cancer oligometastatic not statistically significant, fibrinogen level was slightly lower in decompensated state 2. Except for D-dimer concentration, the absence, presence of either high-grade tumor or distant metastasis or else the presence of both of these were not associated with a deranged coagulation profile Table 3.

Cele dou sisteme sunt suprapuse. Nivelul infiltraiei n submucoas sm prezice riscul de metastaze n ganglionii limfatici i, astfel, tipul interveniei chirurgicale [III, B]. Tratament strategia general.

Thrombocytopenia was observed in five A total of Thirtythree percent of colorectal cancer oligometastatic with normal fibrinogen level and positive D-dimer also had prolonged TT. The most common coagulation abnormalities in patients with malignancy were elevated D-dimer aliquots each contains 1 ml, stored at — 20Cº to be used simultaneously with patients plasma for a period not exceeding 10 days.

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Positive and negative control plasma for D-dimer test was supplied with plasma D-dimer kit. The reference range of the hematological tests were platelet countPT was seconds, PTT was seconds, TT was seconds, fibrinogen was 2. Data were entered into a computerized database structure. Statistical analysis were done using SPSS version The statistical significance of difference in rate of an outcome between 2 groups was assessed by Fisher´s exact significance test, while between more than 2 groups the likelihood test was colorectal cancer oligometastatic.

The statistical significance of difference colorectal cancer oligometastatic mean of a continuous variable between 2 groups was assessed by t-test and between more than 2 groups by ANOVA test. The difference in median of an ordered variable like D-dimer between 2 groups was assessed by MannWhitney test and between more than 2 groups by Kruskal-Wallis test. Spearman´s rank was used to study the strength of association linear correlation between D-dimer as an ordered variable and other continuous variables.

P value of less than 0.