Ovarian high-grade serous carcinoma is a type of malignancy that is rare among young adult women, being more frequent in postmenopausal women. We present the case of a young woman with this type of malignant tumor, who in addition already had extension beyond the pelvis at the time of diagnosis, which is a poor prognostic factor. Case report. We repot the case of a year-old woman who was admitted in our hospital with pelvic pain cancerul in metastaza se vindeca ascites and also with suspicion of peritoneal carcinomatosis.
After complex peritoneal cancer surgery, the histopathological result was bilateral ovarian high-grade serous carcinoma with invasion of the perivesical peritoneum, mesoappendix, multiple omental involvement and one regional lymph node metastasis.
Afterwards, she was submitted for oncologic treatment. The follow-up, three years later, revealed patient survival, but with peritoneal carcinomatosis status on abdominal-pelvic CT scan. Our work brings together reports of young women worldwide facing this form of cancer and underlines the fact that, regardless of age, reproductive women are at risk of developing an aggressive and deadly disease, and that clinical, biological and imaging screening should be increased from an early age.
Keywords high-grade serous carcinoma, young women, screening Rezumat Obiectiv. Carcinomul ovarian seros cu grad înalt de malignitate este un tip de cancer rar întâlnit la femeile tinere, fiind mai peritoneal cancer surgery la femeile în postmenopauză.
- Material and methods: A retrospective study was carried out on series of patients admitted in the period June - March
- Papiloma en la boca como se contagia
- Cancer cerebral tem cura
Не знаю, к чему бы это, только мне все это как-то не нравится.
- peritoneale - Translation into English - examples Romanian | Reverso Context
Vă peritoneal cancer surgery cazul unei femei tinere cu această formă de tumoră malignă, care se afla deja într-un stadiu avansat cu extensie extrapelviană la momentul diagnosticului, ceea ce reprezintă un factor de peritoneal cancer surgery negativ. Prezentare de caz. Raportăm cazul unei femei de 36 de ani care s-a prezentat la spitalul nostru cu dureri pelviene și ascită, suspicionându-se carcinomatoză peritoneală.
După intervenția chirurgicală histerectomie totală cu anexectomie bilaterală, apendicetomie și evidare ganglionară radicalărezultatul histopatologic a fost: carcinom ovarian seros de grad înalt, bilateral, cu invazia peritoneului perivezical, mezoapendice, omentală, precum și a unui limfoganglion regional.
Pacienta a supraviețuit și s-a prezentat periodic la control, însă la trei ani de la operație, la examenul CT abdomino-pelvian, s-au identificat semne de carcinomatoză peritoneală.
Lucrarea noastră aduce în peritoneal cancer surgery plan raportări de cazuri ale unor paciente tinere din întreaga lume suferind de această formă de cancer și subliniază faptul că, indiferent de vârstă, femeile aflate în perioada reproductivă sunt la peritoneal cancer surgery de a dezvolta o afecțiune ovariană agresivă și letală, de aceea este important ca screeningul clinic, biologic și imagistic să fie început de la o vârstă timpurie.
Serous carcinoma is most often diagnosed in the sixth and peritoneal cancer surgery decade, with a mean age of high-grade tumors of 63 years old 3. Diagnosis is often delayed because symptoms are non-specific and include: abdominal pain, distension, gastrointestinal symptoms nausea, anorexia, constipationhigh urinary frequency, vaginal bleeding 1,3. The treatment is represented by surgery and chemotherapy, and although most of them initially respond to chemotherapy, the response is not durable, compared with low-grade serous carcinomas, which are less likely to respond to chemotherapy, but have a more favorable prognosis, based on their indolent growth 4.
Case report We report the case of a year-old woman with previous complains of abdominal pain and moderate abdominal distension who peritoneal cancer surgery admitted in our hospital.
Nicolae Peritoneal cancer surgery, Simona Dima, Vladislav Brasoveanu, Leonard David, Irina Balescu, Raluca Purnichescu-Purtan and Irinel Popescu Rezumat: Abstract Background: The aim of this study was to evaluate whether hepatic resections of ovarian cancer liver metastases provide a benefit in terms of survival as part of primary, secondary, tertiary, and even quaternary cytoreductive surgery. Methods: Data of patients submitted to surgery for ovarian cancer liver metastases at Fundeni Clinical Institute between January and April were retrospectively reviewed. Liver lesions were classified according to their origin in parenchymal and peritoneal lesions.
Following ultrasound examination Figure 1we detected a large left ovarian tumor multiple septa with intense vascularity during Doppler inspection and ascites. After CT examination of the abdomen and pelvis, peritoneal carcinomatosis was suspected. CA and HE4 markers were slightly elevated. Figure 1.
High-grade ovarian serous carcinoma in a young woman - case report and literature review
Figure 2. Macroscopic appearance of the left ovary; note the presence of multiple solid and cystic areas with yellow-brown fluid On macroscopy, both ovaries were enlarged, the left one measuring 90 mm in diameter and the other 5 cm.
Markman M: Intraperitoneal terapie în gestionarea peritoneale mezoteliom. Markman M: Intraperitoneal therapy in the management of peritoneal mesothelioma.
On cut section the left ovary presented multiple solid and cystic areas with yellow-brown fluid Figure 2 ; similar appearance was also detected in the lateral margin of the right ovary. Figure 3. Solid area with severe pleomorphism and numerous mitosis H. Peritoneal cancer surgery area with papillary and micropapillary structures H.
[Antibiotic prophylaxis in surgery for colorectal cancer].
Estrogen receptor positivity - IHC x40 The histopathological examination peritoneal cancer surgery bilateral ovarian high-grade serous carcinoma with invasion of the perivesical peritoneum, mesoappendix, multiple omental involvement and one regional lymph node metastasis stage IIICwith no evidence of metastasis to extraabdominal organs or parenchymal metastasis. The patient was submitted for further oncologic treatment.
Figure 6. In a published study, A. Malpica et peritoneal cancer surgery. The two-tier system of classification of serous carcinoma is composed of low-grade and high-grade tumors. The criteria for sub-classifying to one or the other are histological, represented by nuclear atypia and mitotic activity 3,6. According to age incidence, the low-grade tumors occur at younger age, with statistically declared one decade earlier than high-grade counterpart 1,6.
More than their histological differences, the two serous malignant entities have been described in literature to come along different development pathways. Type I carcinoma low-grade progresses from borderline or benign tumors and are thought to retain their low-grade appearance even after peritoneal cancer surgery recurrence, and type II carcinoma high-grade were described mostly as de novo tumors, although a small percent appear to have evolved from a low-grade tumor 6,7.
Supporting the different pathways are studies demonstrating different genetic alterations, low-grade tumors harbor KRAS and BRAF mutations, whereas high-grade tumors have p53 mutations and sometimes harbor BRCA mutations 3,6.
Other genetic alteration, peritoneal cancer surgery MMR genes in Lynch syndrome, is rarely seen in high-grade serous carcinoma, and is more frequent in non-serous types of ovarian cancer 6, In terms concerning screening, peritoneal cancer surgery is stated in literature that there are no documented effective screening methods that reduce the mortality in ovarian carcinoma.
This supports the rapid onset and possible fulminant behavior of the disease, as de novo cancer, without detectable precancerous lesions.
(PDF) Cancerul-ovariananexa | Gabriela Corhan - bebe-strumf.ro
Additionally, Horvath L. In our case, we have a big tumor dimension, up to 10 cm, and advanced stage disease, but we could not say peritoneal cancer surgery the metastasis began, and do not know if previous screening would have helped the patient in peritoneal cancer surgery earlier tumoral stage. What is sure is peritoneal cancer surgery the diagnosis was not incidental, and addressability to medical care was done when her quality of life was seriously affected.
So, the need for reliable screening tests is an extreme necessity. Conclusions High-grade ovarian serous carcinoma is the most frequent ovarian cancer and it is found mostly in postmenopausal women, but cases of young women, at reproductive age, as in our case, have been reported in literature.
Surgery for Gynecologic Cancer: Mikio Mikami · | Books Express
We found a higher tumor size accompanying advanced tumor stage at the time of diagnosis. Regardless of age, reproductive women are at risk of developing an aggressive and deadly disease, but currently used screening tools need to be more studied regarding their effectiveness, on how often should they be performed or if there can be new screening tests for current use from peritoneal cancer surgery early age.