It is important to distinguish between primary ovarian cancer and metastatic tumors in the ovary because their management is different, in terms of treatment and follow-up.
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We report the perioperative management of a year-old female patient with bilateral Krukenberg tumors. Este important să se facă distincţia între cancerul ovarian primar şi tumorile metastatice ale ovarului, deoarece managementul lor este diferit în ceea ce priveşte tratamentul şi urmărirea. Raportăm managementul perioperator al unei paciente de 40 de ani, cu tumori bilaterale Krukenberg.
Cuvinte cheie tumora Krukenberg cancer gastric imunohistochimie Introduction Ovarian tumors comprise a heterogeneous group of lesions, displaying distinct tumor pathology and oncogenic potential and being subclassified into several cancer abdominal area based on two criteria: the degree of epithelial proliferation and invasion and the histotype of the epithelium composing the tumors 1.
Studiile arată că riscurile cresc odată cu numărul organelor rezecate precum şi cu vârsta pacienților mai mare de 70 ani . Rezultatele studiului nostru concordă cu cele din literatura de specialitate. Astfel, complicațiile pulmonare, mai ales cele trombembolice, cu potențial letal, apar mai frecvent în cazul rezecțiilor multiorgan, cancer abdominal area cu rezecțiile viscerale clasice. Acest fapt se datorează probabil duratei mai mari a intervenției chirurgicale, proporțional cu gradul de dificultate al intervenției, coroborată cu o recuperare postoperatorie mai lentă imobilizare prelungită.
In particular, Krukenberg tumors are represented by metastases of mucin-secreting signet ring cell cancer, arising primarily cancer abdominal area the gastric carcinoma, to ovarian tissues 2. The clinical presentation of Krukenberg tumors includes abdominal or pelvic pain, bloating, ascites, unexplained lethargy, irregular period and pain during sexual intercourse.
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Krukenberg tumors can occasionally provoke a reaction of the ovarian stroma cancer abdominal area leads to hormone production, that results in vaginal bleeding, a change in menstrual habits, hirsutism, or occasionally virilization as a main symptom 5,6. Regarding the paraclinical diagnostic, most imaging features are non-specific, consisting of predominantly solid components or a mixture of cystic and solid areas; typically, cancer abdominal area tumors are described sonographically as bilateral ovarian masses, with an irregular hyperechoic solid pattern, with clear well defined margins and moth-eaten cyst formation 7.
Deep invasion, lymph cancer abdominal area involvement, and peritoneal metastasis are more frequent in gastric SRCC compared with other subtypes of gastric cancer, so the prognosis of Krukenberg tumor is reticent 9. Case report We report the case of a year-old female patient, without a significant pathological personal history, who has been admitted two months ago in the Department of Gynecology of a regional hospital, accusing pelvic pain and dysfunctional menstrual cycles.
She was diagnosed with bilateral ovarian cysts for which reevaluation was recommended.
MORBIDITATE ȘI MORTALITATE ÎN REZECȚIILE MULTIORGAN PENTRU CANCER GASTRIC ȘI COLO-RECTAL.
About 3 weeks ago, the patient was referred to the Department of Obstetrics and Gynecology of University Emergency Hospital in Bucharest for an interdisciplinary consultation. The transvaginal ultrasound showed two non-homogeneous tumors, cancer abdominal area with a tissue aspect, alternating with hypo-echogenic areas and zones of intratumoral necrosis, without capsular breakage; uterus of normal size and echogenity, evidence of fluid within the pouch of Douglas 10 mm.
CA tumor markers were recommended. The local clinical examination revealed normal non-specific vaginosis for which the patient received antibiotic and antiinflammatory treatment for 7 days.
When reevaluating, the patient showed discrete relief of symptoms, with persistence of cancer abdominal area pain, and accusing meteorism. The patient was admitted in the hospital for reevaluation and for establishing the therapeutic conduct. We performed a new transvaginal ultrasound which cancer abdominal area the same aspects, except treatment human papillomavirus vaccine increased peritoneal fluid 30 mm in the recto-uterine pounch - Figure 1 and Figure 2.
Tumoral transformation of the right ovary; non-homogenous structure, predominantly tisular Figure 2. Figure 3. CT of thorax - note the lack of pulmonary metastases Figure 4. CT of pelvis - note the presence of bilateral ovarian tumors with predominant tisular and The general condition of the patient deteriorated, with the cancer abdominal area of vomiting and pain in the right hypochondria and the epigastrium.
Perioperative management of a patient with Krukenberg tumor - a case report
General surgery consultation was requested to exclude a sub-occlusive syndrome, followed by upper endoscopy which showed a normal aspect, with the exception of enlarged folds in the vertical portion of the stomach, but which distended fully under insufflation.
The hematology consult confirmed the diagnosis of coagulopathy of possibly paraneoplastic cancer abdominal area. We decided to improve the coagulopathy by the administration of fresh frozen plasma.
Treating Peritoneal/Abdominal Cancer with "HIPEC"
Under general anesthesia, an exploratory laparotomy was performed see Figure 5. We detected peritoneal carcinomatosis with infra-centimetric disseminations on the epiploon and mesentery.
We also observed free peritoneal fluid in a small amount and multiple liver metastases with various sizes cm. Figure cancer abdominal area. Intraoperative images. A - The macroscopic aspect of the two ovaries that were enlarged, but without capsular breakage; B - The macroscopic aspect of the liver - note the presence of multiple metastases; C - Cancer abdominal area macroscopic aspect of the intestinal loops and mesentery - note peritoneal carcinomatosis; D - Sectioned left ovary - note the presence of large cancer abdominal area that distorted the normal anatomy We decided and practiced tumor cytoreduction through total hysterectomy with bilateral oophorectomy, with the piece being sent to histopathological examination histopathological extemporaneous examination showed undifferentiated ovarian carcinoma with Mullerian cells ; tactical omentectomy and biopsy of all secondary lesions were also performed.
The postoperative evolution was favorable with the improvement of genital symptomatology; the patient was discharged after 5 days and she was guided to the Oncology Department cancer abdominal area follow the specialized treatment after receiving the final histopathological result. After 4 days she returned to the Emergency Room for epigastric pain, vomiting, intense meteorism and absent intestinal transit.
Managementul perioperator al unui pacient cu tumoră Krukenberg - studiu de caz
An abdominal radiography was performed which showed hydroaeric levels. The patient was admitted in the Department of General Surgery with the diagnosis of occlusive syndrome.
- Cancer a genetic disease
Но существовали и особые разновидности саг -- экскурсы в область логики и математики, способные подарить изощреннейшее наслаждение наиболее утонченным умам.
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A surgical reintervention in a multidisciplinary team was performed. Intraoperatively, we found an early adherence syndrome. After an extensive histopathological analysis which included multiple immunohistochemistry tests, the diagnosis of Krukenberg tumors was established Figure 6.
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Figure 6. Histopathological analysis The postoperative evolution was favorable, with improvement of digestive symptomatology; the patient will perform other specialized investigation echo-endoscopy and she was guided to the Oncology Department for specific postoperative treatment.
Возможно, потерянные океаны Земли еще сохраняются глубоко внизу, в вечной тьме, и эта древняя река чувствует зов, влекущий ее к морю.
Кора приставшей земли и камней лишь отчасти скрывала гордые очертания корабля, который все еще величественно вздымался из недр разодранной пустыни.
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Когда был построен парк, узел всей системы движущихся дорог подвергся захоронению.
- Managementul perioperator al unui pacient cu tumoră Krukenberg - studiu de caz
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Discussions Krukenberg tumor is an uncommon metastatic adenocarcinoma of ovaries arising primarily from the gastric carcinoma, which may cause diagnostic confusion with primary ovarian tumors 3. Although he proposed it as a primary tumor of ovary, later it was proved to be secondary to gastrointestinal tract malignancy 4.
Ovaries affected by these tumors retains its shape, irrespective of the size 3.